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My wife and I have subscribed to and been using Elysium supplements since February, 2015.  We began using Basis in 2015, Matter in 2020 and Signal in 2022.

With Basis, I experience  a noticeable increase in our available energy and endurance.  With Matter, my mental acuity has sharpened significantly.  With Signal, instantaneous available energy is noticeable during exercise.

These effects, and an increase in longevity are the main selling points of the products.  Here is what the manufacturer says.

The science of NAD+ is thriving as more research comes out of institutions like Harvard and MIT about the potential benefits of raising NAD+ levels. One recent and very important study co-authored by Elysium Chief Scientist, Dr. Leonard Guarente, showed that increasing NAD+ levels in mice reversed age-related endurance loss. We’re proud to be leading the way in translating this research to human studies. Our clinical trial results, published in November 2017 in Nature Partner Journals: Aging and Mechanisms of Disease, demonstrated that Basis can increase NAD+ safely and sustainably in humans. We have several additional preclinical and clinical trials in progress on Basis, as well as future products in development, that we will share with you soon. As a VIP you’ll have first access.

See also the Time Magazine article

The Science of NAD+, Explained

The coenzyme NAD+ has been called “the golden nucleotide” by one scientist, and the “linchpin of energy metabolism” by Scientific American. It’s the subject of countless preclinical studies indicating that increasing NAD+ levels in lower organisms may have a variety of positive effects on health. We’re especially interested in NAD+ at Elysium: We’ve demonstrated that our first product, Basis, increases NAD+ levels in humans, and we’re working on research to better understand how the gut microbiome affects systemic levels of NAD+. If you’re new to the science of NAD+, here are a few facts to get you started.

NAD+ is a coenzyme found in all living cells.

Coenzymes are colloquially referred to as “helper molecules” because proteins  —  large molecules made of amino acids that do the important biological work in the body  —  require them to do their work. (And they’re called coenzymes because most proteins are enzymes.) If you think of a car as a protein, getting you from place to place so you can go about your life, the gas (or battery if you have a Tesla) is the coenzyme, without which driving is impossible.

But gas (or batteries) can also be used to power any number of other things, from yachts to spacecraft. So too with NAD+, whose chief role is transferring electrons in redox reactions, including oxidative phosphorylation, otherwise known as the metabolic process our body uses to turn food into energy.

Nobel Prize-winning scientists discovered NAD+ more than 100 years ago.

NAD+ was first discovered by Arthur Harden and William John Young in 1906. In 1929, Harden and Hans von Euler-Chelpin won the Nobel Prize in Chemistry for their work on fermentation. They determined that fermentation required the presence of an enzyme (“zymase,” actually a mixture of enzymes) and a coenzyme which they called “cozymase,” now known as NAD+.

Euler-Chelpin further identified the structure of NAD+, which is made of two nucleotides, the building blocks for nucleic acids (the same thing DNA is made of). The role of NAD+ in fermentation, a metabolic process, foreshadowed the critical role that NAD+ plays in metabolic processes in humans.

The science of NAD+ is evolving as more research emerges.

Several important discoveries about NAD+ followed the 1929 Nobel Prize. The most recent discovery happened at MIT, when Dr. Leonard Guarente, founder of Elysium, and Dr. Shin-ichiro Imai observed that sirtuins  —  a family of proteins that have been shown in the laboratory setting to be influential in impacting healthspan  —  only function in the presence of NAD+. (Reminder: Sirtuins are the proteins that do biological work; NAD+ is the coenzyme that allows that work to happen.)

So why are scientists excited? An increasingly detailed picture of NAD+ shows its many functions, from energy creation, to sirtuin activity, to a wide range of other enzymatic activities including mitochondrial function, chromosomal integrity, gene expression, epigenetic and posttranslational modifications, and calcium signaling.

Learn How Basis Increases NAD+   

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